Areca nut procyanidins prevent ultraviolet light B-induced photoaging via suppression of cyclooxygenase-2 and matrix metalloproteinases in mouse skin. (2nd January 2022)

• Record Type: Journal Article
• Authors: Weng, Chia-Ling; Chen, Chih-Chiang; Tsou, Han-Hsing; Liu, Tsung-Yun; Wang, Hsiang-Tsui
• Is Part Of: Drug and chemical toxicology. Volume 45:Number 1(2022)
• Page Start: 353
• Page End: 359
• Publication Date: 2022-01-02
• Subjects: Areca nut procyanidins -- UVB -- photo-aging -- COX2 -- MMP; Toxicology -- Periodicals; Drugs -- Toxicology -- Periodicals; Toxicology, Experimental -- Periodicals; 615.9005
• DOI: 10.1080/01480545.2019.1696813
• Languages: English
• ISSNs: 0148-0545

Abstract

Abstract: Chronic exposure to solar ultraviolet (UV) light induces photoaging in human skin. Our previous results have shown that areca nut procyanidins (ANPs) have antioxidant capacity and possess potential anti-inflammatory effects. Here, we aimed to investigate the effect of ANPs on UVB-induced photoaging. In the present study, dorsal skin of CD-1 mice was exposed to UVB at a minimal erythema dose (130 mJ/cm 2 ) throughout a 3-week period. The effects of ANPs and epigallocatechin-3-gallate (EGCG), a polyphenolic constituent of green tea, on UVB-induced photoaging were compared. The results show that oral administration of ANP prevented UVB-induced photoaging, indicated by epidermal thickness and collagen disorientation, and inhibited UVB-induced expression of cyclooxygenase-2 and matrix metalloproteinases (MMPs), such as MMP-2, MMP-9, and TIMP1. The protective potential of ANP on UVB-induced photodamage was comparable to that of EGCG. These data suggest that ANP could be useful as a dietary supplement to attenuate solar UVB-induced premature skin aging.