A new active peptide from Neptunea arthritica cumingii exerts protective effects against gentamicin-induced sensory-hair cell injury in zebrafish. (2nd January 2022)

• Record Type: Journal Article
• Authors: Zhang, Shanshan; Gao, Yan; He, Qiuxia; Zhang, Yun; Han, Liwen; Jin, Meng; Liu, Tong; Liu, Kechun; Sun, Chen
• Is Part Of: Drug and chemical toxicology. Volume 45:Number 1(2022)
• Page Start: 161
• Page End: 169
• Publication Date: 2022-01-02
• Subjects: Active peptide -- gentamicin -- sensory hair cell -- zebrafish -- ototoxicity; Toxicology -- Periodicals; Drugs -- Toxicology -- Periodicals; Toxicology, Experimental -- Periodicals; 615.9005
• DOI: 10.1080/01480545.2019.1665680
• Languages: English
• ISSNs: 0148-0545

Abstract

Abstract: Gentamicin is commonly used for effective treatment of severe Gram-negative bacterial infections. However, its use is being increasingly restricted owing to the ototoxic effects attributed to it. Gentamicin-induced ototoxicity is thought to be related with apoptosis induced by reactive oxygen species (ROS). In this study, we found a novel active peptide from Neptunea arthritica cumingii with otoprotective effects and no significant embryotoxic effects. The combined application of gentamicin and this novel active peptide helped sensory-hair cells to protect themselves from lethal ROS accumulation. This, in turn, reduced the expression of three genes ( caspase-3, caspase-9, Bax ), and thereby, the sensory-hair cell apoptosis promoted by ROS accumulation upon gentamicin administration. Our findings provided new insights into the prevention of gentamicin-induced hearing loss.