Clinico-radiological findings of neuroendocrine tumour metastases to the orbit. (2nd January 2022)

• Record Type: Journal Article
• Authors: Ryan, T G; Juniat, V; Stewart, C; Malhotra, R; Hardy, T G; McNab, A A; Davis, G; Selva, D
• Is Part Of: Orbit. Volume 41:Number 1(2022)
• Page Start: 44
• Page End: 52
• Publication Date: 2022-01-02
• Subjects: Neuroendocrine tumour -- orbital -- metastases -- carcinoid; Eye-sockets -- Surgery -- Periodicals; Eye-sockets -- Diseases -- Periodicals; Orbit -- surgery -- Periodicals; Orbital Diseases -- Periodicals; 617.7
• DOI: 10.1080/01676830.2021.1895845
• Languages: English
• ISSNs: 0167-6830

Abstract

ABSTRACT: Purpose: We present the clinico-radiological findings of neuroendocrine tumour metastases to the orbit. Methods: This was a multicentre, retrospective study of patients with neuroendocrine tumour metastases to the orbit. Data was collected from medical records across five different sites within Australia and the United Kingdom. Results: Nine patients (eleven lesions) were identified. The most common presenting complaint was diplopia (5/9, 56%). Disease occurred bilaterally in two patients. Seven patients (78%) had extraocular muscle involvement. The lateral recti (4/9, 44%) and superior recti (2/9, 22%) were the most commonly affected. Ocular presentation preceded primary tumour diagnosis in three patients (33%). On orbital imaging, metastases were most commonly reported as well circumscribed, ovoid or round, heterogeneous, contrast-enhancing masses. Features of intralesional haemorrhage and bony invasion are uncommonly reported. Conclusions: Neuroendocrine tumour metastasis to the orbit is uncommon. Metastases have a propensity for the extraocular muscles, commonly presenting as heterogeneous, well circumscribed, contrast-enhancing lesions on neuroimaging. New ocular symptoms, a history of neuroendocrine tumours, and these radiological findings, should lead to high clinical suspicion of metastatic disease. Atypical findings warrant biopsy to exclude other causes of orbital lesions.