Genomic Epidemiology and Transmission Dynamics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Congregate Healthcare Facilities in Santa Clara County, California. (30th July 2021)

• Record Type: Journal Article
• Authors: MacCannell, Tara; Batson, Joshua; Bonin, Brandon; Astha, K C; Quenelle, Rebecca; Strong, Betsy; Lin, Wen; Rudman, Sarah L; Dynerman, David; Ayscue, Patrick; Han, George; Kistler, Amy; Villarino, Margarita Elsa
• Is Part Of: Clinical infectious diseases. Volume 74:Number 5(2022)
• Page Start: 829
• Page End: 835
• Publication Date: 2021-07-30
• Subjects: elderly -- epidemiology -- genomics -- healthcare -- providers; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab553
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Background: Outbreaks of SARS-CoV-2 in long-term care facilities (LTCFs) cause significant morbidity and mortality. Mapping viral transmission within and between facilities by combining genomic sequencing with epidemiologic investigations enables targeting infection-control interventions. Methods: We conducted weekly surveillance of residents and staff in LTCFs in Santa Clara County, California, with ≥1 confirmed COVID-19 case between March and July 2020. Positive samples were referred for whole-genome sequencing. Epidemiological investigations and phylogenetic analyses of the largest outbreaks (>30 cases) were carried out in 6 LTCFs (Facilities A through F). Results: Among the 61 LTCFs in the county, 41 had ≥1 confirmed case during the study period, triggering weekly SARS-CoV-2 testing. The 6 largest outbreaks accounted for 60% of cases and 90% of deaths in LTCFs, although the bed capacity of these facilities represents only 11% of the LTCF beds in the county. Phylogenetic analysis of 196 whole-genome sequences recovered from those facilities showed that each outbreak was monophyletic, with staff and residents sharing a common viral lineage. Outbreak investigations revealed that infected staff members often worked at multiple facilities, and in 1 instance, a staff member infected while working in 1 facility was the likely index case in another. Conclusions: We detected a pattern of rapid and sustained transmission after a single introduction of SARS-CoV-2 in 6 large LTCF outbreaks, with staff playing a key role in transmission within and between facilities. Infection control, testing, and occupational policies to reduce exposure and transmission risk for staff are essential components to keeping facility residents safe. Abstract : Genomic sequences from 196 staff and residents of LTCFs in Santa Clara County, California, characterized transmission of SARS-CoV-2 in congregate settings. Timely pairing of epidemiologic and clinical data with genomic sequencing is an important tool to refine SARS-CoV-2 mitigation strategies.