ECCO Topical Review on Clinicopathological Spectrum and Differential Diagnosis of Inflammatory Bowel Disease. (4th August 2021)

• Record Type: Journal Article
• Authors: Feakins, Roger; Torres, Joana; Borralho-Nunes, Paula; Burisch, Johan; Cúrdia Gonçalves, Tiago; De Ridder, Lissy; Driessen, Ann; Lobatón, Triana; Menchén, Luis; Mookhoek, Aart; Noor, Nurulamin; Svrcek, Magali; Villanacci, Vincenzo; Zidar, Nina; Tripathi, Monika
• Is Part Of: Journal of Crohn's and colitis. Volume 16:Number 3(2022)
• Page Start: 343
• Page End: 368
• Publication Date: 2021-08-04
• Subjects: Inflammatory bowel diseases -- ulcerative colitis -- Crohn's disease -- tuberculosis -- parasitic infections -- viral infections -- bacterial infections -- fungal infections -- drug-induced abnormalities -- immune checkpoint inhibitors -- diverticulosis -- vasculitis -- ischaemic colitis -- radiation-induced abnormalities -- endoscopy -- pathology -- diagnostic imaging; Inflammatory bowel diseases -- Periodicals; 616.344005
• DOI: 10.1093/ecco-jcc/jjab141
• Languages: English
• ISSNs: 1873-9946

Abstract

Abstract: Introduction: Many diseases can imitate inflammatory bowel disease [IBD] clinically and pathologically. This review outlines the differential diagnosis of IBD and discusses morphological pointers and ancillary techniques that assist with the distinction between IBD and its mimics. Methods: European Crohn's and Colitis Organisation [ECCO] Topical Reviews are the result of an expert consensus. For this review, ECCO announced an open call to its members and formed three working groups [WGs] to study clinical aspects, pathological considerations, and the value of ancillary techniques. All WGs performed a systematic literature search. Results: Each WG produced a draft text and drew up provisional Current Practice Position [CPP] statements that highlighted the most important conclusions. Discussions and a preliminary voting round took place, with subsequent revision of CPP statements and text and a further meeting to agree on final statements. Conclusions: Clinicians and pathologists encounter a wide variety of mimics of IBD, including infection, drug-induced disease, vascular disorders, diverticular disease, diversion proctocolitis, radiation damage, and immune disorders. Reliable distinction requires a multidisciplinary approach.