Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA. (3rd June 2021)

• Record Type: Journal Article
• Authors: Klein, Sabrina; Boutin, Sébastien; Kocer, Kaan; Fiedler, Mascha O; Störzinger, Dominic; Weigand, Markus A; Tan, Benjamin; Richter, Daniel; Rupp, Christian; Mieth, Markus; Mehrabi, Arianeb; Hackert, Thilo; Zimmermann, Stefan; Heeg, Klaus; Nurjadi, Dennis
• Is Part Of: Clinical infectious diseases. Volume 74:Number 5(2022)
• Page Start: 905
• Page End: 908
• Publication Date: 2021-06-03
• Subjects: antibiotic resistance -- carbapenemase -- Cefiderocol -- cirA siderophore receptor -- Enterobacter cloacae; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab511
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.