Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms. (21st March 2021)

• Record Type: Journal Article
• Authors: Cunningham, Janet L; Virhammar, Johan; Rönnberg, Bengt; Dopico, Xaquin Castro; Kolstad, Linda; Albinsson, Bo; Kumlien, Eva; Nääs, Anja; Klang, Andrea; Westman, Gabriel; Zetterberg, Henrik; Frithiof, Robert; Lundkvist, Åke; Karlsson Hedestam, Gunilla B; Rostami, Elham
• Is Part Of: Journal of infectious diseases. Volume 225:Number 6(2022)
• Page Start: 965
• Page End: 970
• Publication Date: 2021-03-21
• Subjects: COVID-19 -- SARS-CoV-2 -- serology -- CSF -- IgG -- neurological symptoms; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab153
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serum and cerebrospinal fluid (CSF) samples from 16 patients with coronavirus disease 2019 and neurological symptoms were assessed using 2 independent methods. Immunoglobulin G (IgG) specific for the virus spike protein was found in 81% of patients in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in 2 patients with negative serological findings. Levels of IgG in both serum and CSF were associated with disease severity ( P < .05). All patients with elevated markers of central nervous system damage in CSF also had CSF antibodies ( P = .002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables. Abstract : Patients with coronavirus disease 2019 and neurological symptoms had immunoglobulin G against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S/S1 protein in both serum (81%) and cerebrospinal fluid (56%). All patients with elevated markers of central nervous system damage also had immunoglobulin G against SARS-CoV-2 in cerebrospinal fluid.