Chronic obstructive pulmonary disease as a risk factor for suicide: A systematic review and meta-analysis. (May 2019)

• Record Type: Journal Article
• Authors: Sampaio, Marcelo S.; Vieira, Walbert de A.; Bernardino, Ítalo de M.; Herval, Álex Moreira; Flores-Mir, Carlos; Paranhos, Luiz R.
• Is Part Of: Respiratory medicine. Volume 151(2019)
• Page Start: 11
• Page End: 18
• Publication Date: 2019-05
• Subjects: Chronic obstructive pulmonary disease -- Suicide -- Risk factors; Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2019.03.018
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: Background: Patients living with chronic obstructive pulmonary disease (COPD) commonly present several limitations in their daily activities, high depression rates, and low quality of life, which makes this population a risk group for suicide. This study aims to systematically assess the literature on the association between CPOD and the likelihood of suicide. Methods: The protocol was registered in PROSPERO (CRD42018096618). The Latin-American and Caribbean Health Sciences Literature (LILACS), PubMed, SciELO, Scopus, LIVIVO, Web of Science, and PsychNET databases were used as primary study sources. OpenThesis and OpenGrey were used to partially capture the "grey literature". A manual search was also performed through a systematized analysis of the references of eligible articles. The risk of bias among the studies included was assessed with the Joanna Briggs Institute Critical Appraisal Tools for Systematic Reviews. A random effects meta-analysis was performed to estimate the variation in odds ratio (OR) and 95% confidence intervals (95% CI). Results: The search provided 4762 results, from which only seven met the eligibility criteria and were ultimately included in the qualitative assessment of the review. The studies were published from 2002 to 2015. All studies presented low risk of bias. The total sample included 1390 suicide cases of COPD patients. The meta-analysis, which was based on five eligible case control studies, found that people with history of COPD are more likely to commit suicide (OR = 1.90; 95% CI = 1.27–2.48; p = 0.002). Conclusion: COPD patients are 1.9 times more likely to commit suicide than people without COPD. Highlights: COPD patients have a higher likelihood of suicide than non-carriers of the disease. Women with COPD have a higher risk of committing suicide than men. There are no studies assessing suicide and COPD in developing countries. Moderate quality of evidence according to GRADE.