The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity. (12th June 2021)

• Record Type: Journal Article
• Authors: Pollett, Simon D; Richard, Stephanie A; Fries, Anthony C; Simons, Mark P; Mende, Katrin; Lalani, Tahaniyat; Lee, Tida; Chi, Sharon; Mody, Rupal; Madar, Cristian; Ganesan, Anuradha; Larson, Derek T; Colombo, Christopher J; Colombo, Rhonda; Samuels, Emily C; Broder, Christopher C; Laing, Eric D; Smith, Darci R; Tribble, David; Agan, Brian K; Burgess, Timothy H
• Is Part Of: Clinical infectious diseases. Volume 74:Number 5(2022)
• Page Start: 897
• Page End: 900
• Publication Date: 2021-06-12
• Subjects: SARS-CoV-2 -- vaccine breakthrough -- symptoms -- patient-reported outcomes -- live virus; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab543
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Little is known about severe acute respiratory syndrome coronavirus 2 "vaccine-breakthrough" infections (VBIs). Here we characterize 24 VBIs in predominantly young healthy persons. While none required hospitalization, a proportion endorsed severe symptoms and shed live virus as high as 4.13 × 10 3 plaque-forming units/mL. Infecting genotypes included both variant-of-concern (VOC) and non-VOC strains.