Immune sunrise: from the immunome to the cancer immune landscape. (31st December 2022)

• Record Type: Journal Article
• Authors: Bindea, Gabriela; Mlecnik, Bernhard; Galon, Jérôme
• Is Part Of: Oncoimmunology. Volume 11:Number 1(2022)
• Publication Date: 2022-12-31
• Subjects: T-cells -- tumor microenvironment -- colorectal cancer -- prognosis -- survival -- immunity -- immunoscore -- immune landscape -- immunotherapy -- chemotherapy; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2021.2019896
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: The complex dynamics of the tumor-immune interaction during tumor progression have been characterized by integrating genomic and proteomic experiments. The Immunome, a reference compendium of markers for the majority of immune cell subpopulations was used to describe the immune landscape in cancer. The immune contexture is at the cornerstone in the success of cancer immunotherapies. Markers with the highest clinical relevance were summarized as the consensus immunoscore. This immune evaluation refines the prognosis of the patients and the chemotherapy decision-making process and was introduced as essential and desirable diagnostic criteria into three major international guidelines.