Contact Allergy Cross-reactions and Thresholds: A Review. Issue 2 (2nd March 2022)

• Record Type: Journal Article
• Authors: Scheman, Andrew; Ruggiero, Jenna L.; Kerchinsky, Lillian; Zippin, Jonathan H.; Zirwas, Matthew; Lugo-Somilinos, Aida; Hylwa, Sara
• Is Part Of: Dermatitis. Volume 33:Issue 2(2022)
• Page Start: 106
• Page End: 109
• Publication Date: 2022-03-02
• Subjects: Skin -- Inflammation -- Periodicals; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; Dermatitis, Contact -- Periodicals; Dermatitis, Atopic -- Periodicals; Dermatitis, Occupational -- Periodicals; Drug Eruptions -- Periodicals; 616.51
• DOI: 10.1097/DER.0000000000000798
• Languages: English
• ISSNs: 1710-3568

Abstract

Abstract: Consideration of contact allergen concomitant reactivity, which encompasses cross-reactors, co-reactors, and pseudo cross-reactors, is an important aspect of patient care, yet information on how these terms are differentiated and used in clinical practice is lacking. In this review, we provide definitions of cross-reactors, coreactors, and pseudo cross-reactors and discuss the utility of the American Contact Dermatitis Society Contact Allergen Management Program database cross-reactor groupings. We also discuss limitations to the current categorization of cross-reactivity and recommend incorporating new terms, including "apparent cross-reactor" and "derivative cross-reactor, " when classifying cross-reactors.