Genetic profile of primary plasma cell leukemia in Korea: comparison with plasma cell myeloma. Issue 2 (28th January 2022)

• Record Type: Journal Article
• Authors: Lee, Youngeun; Yun, Jiwon; Jeong, Dajeong; Ryu, Sohee; Kwon, Seok Ryun; Yun, Hongseok; Kim, Sung Min; Park, Jae Hyeon; Lee, Dong Soon
• Is Part Of: Leukemia & lymphoma. Volume 63:Issue 2(2022)
• Page Start: 385
• Page End: 394
• Publication Date: 2022-01-28
• Subjects: Primary plasma cell leukemia -- genetic profiling -- multiple myeloma -- secondary plasma cell leukemia; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2021.1983568
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Plasma cell leukemia (PCL) is clinically and genetically distinct from multiple myeloma (MM), despite controversies regarding the disease definition. To determine the distinct features of PCL, the genetic property of primary PCL (pPCL) was compared with that of secondary PCL (sPCL) and MM. In patients with pPCL, Eighty-nine non-synonymous mutations were observed in 68 genes. The most frequently mutated genes were TP53, TSC2, and TYK2. In comparison with genetic abnormalities of sPCL and MM, 45 genes were present only in pPCL while 28 genes were only in sPCL and 22 genes only in MM. Among the common genes between pPCL and MM, a higher prevalence of TP53 was observed in pPCL, compared to MM ( p < 0.05), while similar, compared to sPCL ( p = 0.64). In summary, pPCL patients showed a higher level of genetic heterogeneity and distinctive genetic signature in their mutational profile compared to patients with MM and sPCL.