Fabrication of gold-immobilized quantum dots/silica core–shell nanoparticles and their multimodal imaging properties. (17th February 2022)

• Record Type: Journal Article
• Authors: Tayama, M.; Inose, T.; Yamauchi, N.; Nakashima, K.; Tokunaga, M.; Kato, C.; Gonda, K.; Kobayashi, Y.
• Is Part Of: Particulate science and technology. Volume 40:Number 2(2022)
• Page Start: 252
• Page End: 260
• Publication Date: 2022-02-17
• Subjects: Quantum dot -- gold -- silica-coating -- core–shell -- nanoparticle -- fluorescence imaging -- x-ray imaging; Particles -- Periodicals; 620.43
• DOI: 10.1080/02726351.2021.1934918
• Languages: English
• ISSNs: 0272-6351

Abstract

Abstract: This work describes the fabrication of quantum dot (QD)/silica (SiO2 ) core–shell particles immobilized with Au nanoparticles and the evaluation of their abilities in fluorescence and x-ray computed tomography (CT) imaging. The QD nanoparticles were coated with silica shells by a sol-gel method using tetraethyl orthosilicate (QD/SiO2 ). Reduction of Au 3+ in a citrate aqueous solution gave an Au nanoparticle colloidal solution. (3-Mercaptopropyl)trimethoxysilane thiolated the QD/SiO2 particle surface (QD/SiO2 /SH). Immobilization of the Au nanoparticles on the QD/SiO2 /SH particle surface was performed with the addition of the Au nanoparticle colloidal solution to the QD/SiO2 /SH nanoparticle colloidal solution (QD/SiO2 /SH/Au). Surface-PEGylated QD/SiO2 /SH/Au particles were fabricated using thiol-terminated polyethylene glycol (PEG) (QD/SiO2 /SH/Au/PEG). The QD/SiO2 /SH/Au/PEG nanoparticle colloidal solution was imaged by fluorescence and x-ray CT imaging techniques. The CT value per unit concentration of Au (M) for the QD/SiO2 /SH/Au/PEG nanoparticle colloidal solution was 1.5 × 10 4 HU/M. The QD/SiO2 /SH/Au/PEG nanoparticle colloidal solution was injected into the tail vein of a mouse and circulated in the blood, although some QD/SiO2 /SH/Au/PEG nanoparticles were trapped and remained in the liver and spleen.