Two cases of pineal anlage tumor with molecular analysis. Issue 4 (7th February 2022)

• Record Type: Journal Article
• Authors: Scherpelz, Kathryn P.; Crotty, Erin E.; Paulson, Vera A.; Lockwood, Christina M.; Leary, Sarah E. S.; Ellenbogen, Richard G.; Lee, Amy; Ermoian, Ralph P.; Vitanza, Nicholas A.; Cole, Bonnie L.
• Is Part Of: Pediatric blood & cancer. Volume 69:Issue 4(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-07
• Subjects: copy number variant -- molecular analysis -- pediatric pineal neoplasm -- pineal anlage tumor -- pineoblastoma; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.29596
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Pineal anlage tumor is a rare pediatric tumor with clinical and histological features overlapping with pineoblastoma. Two patients with pineal anlage tumor, a 13‐month‐old female and an 11‐month‐old male, underwent subtotal resection, high‐dose chemotherapy with autologous stem cell rescue, and radiation. Neither had tumor progression 50 months after diagnosis. The tumors underwent next‐generation sequencing on a panel of 340 genes. Chromosomal copy gains and losses were present and differed between the tumors. No mutations or amplifications, including none specific to pineoblastoma, were identified.