Photoredox catalyzed cascade CF3 addition/chemodivergent annulations of ortho-alkenyl aryl ureas. Issue 12 (20th January 2022)

• Record Type: Journal Article
• Authors: Babu, Sakamuri Sarath; Varma, A Anagha; Gopinath, Purushothaman
• Is Part Of: Chemical communications. Volume 58:Issue 12(2022)
• Page Start: 1990
• Page End: 1993
• Publication Date: 2022-01-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc06289a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Photoredox catalyzed cascade addition-chemodivergent annulations of ortho -alkenyl aryl ureas. Abstract : Herein, we report a substrate-controlled cascade cyclization of o -alkenyl aryl ureas, an ambident nucleophile for constructing functionalized heterocycles such as 2-amino-1, 3-benzoxazines and dihydroquinazolinones in a chemodivergent fashion using photoredox catalysis under mild conditions. The versatility of the method has been successfully demonstrated by applying this strategy to a wide range of substrates and for the synthesis of functionalized etifoxine drug derivatives.