Rhodium(iii)-catalyzed cascade C–H functionalization/annulation of sulfoximines with iodonium ylides for the synthesis of cyclohexanone-1, 2-benzothiazines. Issue 4 (12th January 2022)

• Record Type: Journal Article
• Authors: Chen, Lu; Wang, Zhichao; Wang, Yangyang; Hao, Liqiang; Xu, Xiaobo; Wu, Gaorong; Ji, Yafei
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 4(2022)
• Page Start: 887
• Page End: 894
• Publication Date: 2022-01-12
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob02110a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A highly efficient Rh(iii )-catalyzed cascade C–H activation/annulation of sulfoximines with iodonium ylides under metal-oxidant-free conditions has been reported. Abstract : A highly efficient Rh(iii )-catalyzed cascade C–H activation/annulation of sulfoximines with iodonium ylides under metal-oxidant-free conditions has been reported. The fused cyclohexanone-1, 2-benzothiazine scaffold is readily achieved with a one-pot process in this reaction. This protocol exhibits good functional group tolerance and moderate to excellent yields. Additionally, the olefination of the target product illustrates the promising usefulness of this strategy.