Copper-promoted difunctionalization of unactivated alkenes with silanes. Issue 5 (12th January 2022)

• Record Type: Journal Article
• Authors: Xue, Yingying; Guo, Zhuangzhuang; Chen, Xiaoyu; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 5(2022)
• Page Start: 989
• Page End: 994
• Publication Date: 2022-01-12
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob02318g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient copper-catalyzed cascade difunctionalization of N -allyl anilines toward the synthesis of silylated indolines using commercially available silanes has been reported. Abstract : An efficient copper-catalyzed cascade difunctionalization of N -allyl anilines toward the synthesis of silylated indolines using commercially available silanes has been reported. This strategy provides a new avenue for the synthesis of a diverse array of indolines in reasonable yields. Preliminary mechanistic investigations indicate that the reaction probably proceeds via a radical pathway with unactivated alkenes as radical acceptors and simple silanes as radical precursors. This protocol is distinguished by its atom economy, broad substrate scope and readily available starting materials.