A quantitative evaluation of the histological type dependence of the programmed death-ligand 1 expression in non-small cell lung cancer including various adenocarcinoma subtypes: a cross-sectional study. (29th December 2021)

• Record Type: Journal Article
• Authors: Kojima, Kensuke; Sakamoto, Tetsuki; Kasai, Takahiko; Atagi, Shinji; Yoon, Hyungeun
• Is Part Of: Japanese journal of clinical oncology. Volume 52:Number 3(2022)
• Page Start: 281
• Page End: 285
• Publication Date: 2021-12-29
• Subjects: programmed death-ligand 1 -- non-small cell lung cancer -- adenocarcinoma subtypes -- multiple regression analysis; Oncology -- Periodicals; Cancer -- Periodicals; 616.994005
• DOI: 10.1093/jjco/hyab202
• Languages: English
• ISSNs: 0368-2811

Abstract

Abstract: The association between non-small cell lung cancer histology and programmed death-ligand 1 expression remains controversial. We retrospectively analyzed histological dependence of the programmed death-ligand 1 expression by a multiple regression analysis of 356 non-small cell lung cancer patients. The programmed death-ligand 1 expression patterns of adenocarcinoma were consistent with a pathological predominant growth pattern as a reference to papillary adenocarcinoma: minimally invasive adenocarcinoma[partial regression coefficient (B), 0.17; 95% confidence interval, 0.05–0.59], lepidic adenocarcinoma (B, 0.46; 95% confidence interval, 0.23–0.90), acinar adenocarcinoma (B, 1.98; 95% confidence interval, 1.05–3.76) and solid adenocarcinoma (B, 5.11; 95% confidence interval, 2.20–11.9). In histology other than adenocarcinoma, the programmed death-ligand 1 expression tended to be high with poor differentiation: adenosquamous carcinoma (B, 4.17; 95% confidence interval, 1.05–16.6), squamous cell carcinoma (B, 4.32; 95% confidence interval, 2.45–7.62) and pleomorphic carcinoma (B, 13.0; 95% confidence interval, 4.43–38.2). We showed quantitatively that the programmed death-ligand 1 expression in non-small cell lung cancer tended to be clearly histology-dependent, with more poorly differentiated histology showing a higher expression. Abstract : A mathematical model of a multiple regression analysis quantitatively revealed that the programmed death-ligand 1 expression in non-small cell lung cancer tended to progressively strengthen as the histological type became poorly differentiated.