A highly selective and sensitive electrochemical sensor for dopamine based on a functionalized multi-walled carbon nanotube and poly(N-methylaniline) composite. Issue 4 (14th January 2022)

• Record Type: Journal Article
• Authors: Direksilp, Chatrawee; Scheiger, Johannes M.; Ariyasajjamongkol, Nuttha; Sirivat, Anuvat
• Is Part Of: Analytical methods. Volume 14:Issue 4(2022)
• Page Start: 469
• Page End: 479
• Publication Date: 2022-01-14
• Subjects: Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; Chemical laboratories -- Standards -- Periodicals; 543.1905
• DOI: 10.1039/d1ay01943k
• Languages: English
• ISSNs: 1759-9660

Abstract

Abstract : A poly( N -methylaniline) composite, shown for the first time, is well-suited to sense dopamine due to a low LOD (2.23 μmol L −1 ). Abstract : Dopamine (DA) is an important neurotransmitter used for diagnosing various diseases from its abnormal concentrations in human fluids. Herein, an electrochemical sensor based on a composite of re-doped poly( N -methylaniline) (rePNMA) and modified multi-walled carbon nanotubes (fMWCNTs), termed fMWCNT-rePNMA, was developed to measure DA concentration. The successful modification of the fMWCNT surface was confirmed by Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Cyclic voltammetry (CV) displayed an excellent electrocatalytic activity of the fMWCNTs-rePNMA composite towards the oxidation of DA. The developed fMWCNTs-rePNMA composite demonstrated a broad linear range from 5 to 90 μmol L −1 with a low limit of detection (LOD) value of 2.23 μmol L −1, and a fast response with a high sensitivity of 251.5 nA μmol −1 L as determined from the calibration curve of the DA determination. In addition, the fMWCNTs-rePNMA composite selectively identified and quantified DA in the presence of ascorbic acid (AA) and uric acid (UA). Therefore, the fMWCNTs-rePNMA composite sensor shows potential to determine the level of DA in human urine.