Sensitive electrochemiluminescence analysis of lung cancer marker miRNA-21 based on RAFT signal amplification. Issue 11 (13th January 2022)

• Record Type: Journal Article
• Authors: Wang, Qingyu; Yu, Shuaibing; Zhang, Lianshun; Wang, Lei; Kong, Jinming; Li, Lianzhi; Zhang, Xueji
• Is Part Of: Chemical communications. Volume 58:Issue 11(2022)
• Page Start: 1701
• Page End: 1703
• Publication Date: 2022-01-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc06738a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An electrochemiluminescence sensor based on surface-initiated reversible addition–fragmentation chain transfer (SI-RAFT) signal amplification. Abstract : An electrochemiluminescence approach based on surface-initiated reversible addition–fragmentation chain transfer (SI-RAFT) was developed for miRNA-21 detection for the first time. The SI-RAFT polymerization generates polymer chains with functional groups that are used to recruit luminol, enabling strong ECL signal output with low concentrations of miRNA-21, and greatly improving the detection sensitivity.