Association of fasting orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescents. (April 2022)

• Record Type: Journal Article
• Authors: Lanuza, Fabian; Reyes, Marcela; Blanco, Estela; Burrows, Raquel; Peirano, Patricio; Algarín, Cecilia; Meroño, Tomás; Gahagan, Sheila
• Is Part Of: Psychoneuroendocrinology. Volume 138(2022)
• Publication Date: 2022-04
• Subjects: BMI body mass index -- OR odds ratio -- MetS metabolic syndrome -- OW overweight -- OB obese; Adolescent -- Orexin -- Caloric intake -- Obesity -- Appetite; Psychoneuroendocrinology -- Periodicals; Endocrinology -- Periodicals; Neurology -- Periodicals; Psychiatry -- Periodicals; Neuropsychoendocrinologie -- Périodiques; 616.8
• DOI: 10.1016/j.psyneuen.2022.105679
• Languages: English
• ISSNs: 0306-4530

Abstract

Abstract: Orexin-A, a hormone secreted by orexin neurons, is involved in caloric-intake regulation. Current understanding is based primarily on animal studies. Studies of orexin in humans are scarce, and to our knowledge there are no prior studies in adolescents. We studied fasting Orexin-A levels related to energy intake at breakfast and a subsequent snack in adolescents (n = 668) from a longitudinal study in Chile. Body-Mass Index (BMI), components of the metabolic syndrome and fasting blood levels of leptin, insulin, ghrelin, and orexin-A were measured. Energy intake was calculated based on food weights before and after the standardized breakfast and subsequent snack. High energy intake was defined as ≥ 75th percentile. We assessed the relationship between orexin-A and high energy intake, adjusting for confounders. Higher orexin levels were associated with high breakfast energy intake (OR: 1.21; 95%CI: 0.98–1.49). Conversely, those with higher orexin levels showed a non-significant trend for lower odds of high energy intake for the snack (OR: 0.87; 95%CI: 0.70–1.07). There was a significant interaction between high breakfast energy intake and orexin levels. Those who ate more calories at breakfast displayed a lower inhibitory effect of orexin on eating at the snack (p < 0.05). There was no significant interaction between weight status and orexin. In conclusion, orexin-A levels were associated with breakfast energy intake and inversely related with subsequent snack energy intake in participants whose caloric intake at breakfast was within the normal range. Based on these findings, it appears that the association of orexin-A with energy intake depends on eating behavior. Highlights: Higher orexin levels were associated with high breakfast energy intake. Higher orexin was associated with lower odds of caloric intake at a snack if participants consumed a high-calorie breakfast. Lower levels of orexin were associated with higher caloric intake at the snack offered after breakfast.