Ruthenium‐Catalyzed Vinylene Carbonate Annulation by C−H/N−H Functionalizations: Step‐Economical Access to Indoles. Issue 4 (5th January 2022)

• Record Type: Journal Article
• Authors: Yu, Yao; Wang, Yang; Li, Bo; Tan, Yuqiang; Zhao, Huan; Li, Zheyu; Zhang, Chunran; Ma, Wenbo
• Is Part Of: Advanced synthesis & catalysis. Volume 364:Issue 4(2022)
• Page Start: 838
• Page End: 844
• Publication Date: 2022-01-05
• Subjects: ruthenium catalyst -- annulation -- C−H/N−H functionalization -- vinylene carbonate -- indole.; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202101466
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A convenient and effective method of ruthenium‐catalyzed C−H/N−H annulations using vinylene carbonate as oxidizing acetylene surrogate has been disclosed. This method is scalable and compatible with a wide range of functional groups, providing a step‐economical access to indole synthesis Preliminary mechanistic studies provided support for a reversible, acetate‐assisted C−H ruthenation, along with a subsequent olefin insertion. Abstract :