Chiral FLP-catalyzed asymmetric hydrogenation of 3-fluorinated chromones. Issue 10 (11th January 2022)

• Record Type: Journal Article
• Authors: Dai, Yun; Meng, Wei; Feng, Xiangqing; Du, Haifeng
• Is Part Of: Chemical communications. Volume 58:Issue 10(2022)
• Page Start: 1558
• Page End: 1560
• Publication Date: 2022-01-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc06964k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : With an FLP composed of achiral borane and chiral oxazoline as the catalyst, the metal-free asymmetric hydrogenation of 3-fluorinated chromones has been successfully realized, affording the desired products in high yields with up to 88% ee. Abstract : The asymmetric hydrogenation of fluorinated olefins is an efficient pathway towards the synthesis of chiral fluorine-containing compounds. This paper described metal-free asymmetric hydrogenation of 3-fluorinated chromones with the use of readily available achiral borane and chiral oxazoline as an FLP catalyst for the first time. A variety of optically active 3-fluorochroman-4-ones were obtained in high yields with up to 88% ee.