Combining bio- and organocatalysis for the synthesis of piperidine alkaloids. Issue 11 (13th January 2022)

• Record Type: Journal Article
• Authors: Taday, Freya; Cairns, Ryan; O'Connell, Adam; O'Reilly, Elaine
• Is Part Of: Chemical communications. Volume 58:Issue 11(2022)
• Page Start: 1697
• Page End: 1700
• Publication Date: 2022-01-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc03865f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A hybrid bio-organocatalytic cascade was developed for the preparation of piperidine alkaloids. Abstract : There is continued interest in developing cascade processes for the synthesis of key chiral building blocks and bioactive natural products (or analogues). Here, we report a hybrid bio–organocatalytic cascade for the synthesis of a small panel of 2-substituted piperidines, relying on a transaminase to generate a key reactive intermediate for the complexity building Mannich reaction.