A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans. Issue 10 (7th January 2022)

• Record Type: Journal Article
• Authors: García-García, Amalia; Rojas, Sara; Rivas-García, Lorenzo; Navarro-Hortal, María D.; Romero-Márquez, Jose M.; Fernández-Bolaños, José G.; Choquesillo-Lazarte, Duane; Salinas-Castillo, Alfonso; López, Óscar; Quiles, José L.; Rodríguez-Diéguez, Antonio
• Is Part Of: Chemical communications. Volume 58:Issue 10(2022)
• Page Start: 1514
• Page End: 1517
• Publication Date: 2022-01-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc04404d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A new palladium coordination compound shows promising protective activity against Aβ-induced toxicity. Abstract : A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2 ] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd 2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme–substrate complex. Finally, the palladium compound shows promising protective activity against Aβ-induced toxicity in the Caenorhabditis elegans model, which has never been reported.