A biomimetic ZIF nanoagent for synergistic regulation of glutamine metabolism and intracellular acidosis of cancer. Issue 10 (11th January 2022)

• Record Type: Journal Article
• Authors: Wang, Mengzhen; Lu, Fei; Li, Na; Pan, Wei; Tang, Bo
• Is Part Of: Chemical communications. Volume 58:Issue 10(2022)
• Page Start: 1554
• Page End: 1557
• Publication Date: 2022-01-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc05903c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A homotypic cancer cell membrane camouflaged ZIF-based nanoagent was developed to improve anticancer efficiency through synergistic metabolism regulation and acidosis aggravation. Abstract : A homotypic cancer cell membrane camouflaged zeolitic imidazolate framework (ZIF)-based nanoagent with co-loading of two inhibitors was developed, which could suppress the efflux of protons to induce intracellular acidic stress and down-regulate glutamine metabolism to reduce the energy supply. As a compensation, glycometabolism would be upregulated with simultaneous production of large amounts of lactic acid, which could in turn aggravate the acidosis and further realize a synergetic cancer treatment.