Autoimmune polyglandular syndrome type 3: A case report of an unusual presentation and literature review. Issue 2 (4th February 2022)

• Record Type: Journal Article
• Authors: Apolinario, Michael; Brussels, Aaron; Cook, Curtiss B.; Yang, Shaun
• Is Part Of: Clinical case reports. Volume 10:Issue 2(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-04
• Subjects: autoimmune polyglandular syndrome -- cobalamin deficiency -- subacute combined degeneration -- thyroid autoimmune disease -- pernicious anemia -- vitamin B12 deficiency; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.5391
• Languages: English
• ISSNs: 2050-0904

Abstract

Abstract: Autoimmune polyglandular syndromes (APS) are rare disorders characterized by auto‐destruction of endocrine and non‐endocrine organs by organ‐specific antibody‐directed T‐lymphocytic infiltration. This case highlights a 29‐year‐old Caucasian man with vitiligo found to have significant neurological abnormalities in the setting of newly diagnosed pernicious anemia and thyroid autoimmune disease. Abstract : Autoimmune polyglandular syndromes can have widely variable presentations. If a patient is found to have newly diagnosed thyroid autoimmune disease, it would be valuable to screen for other autoimmune diseases such as pernicious anemia; as these associated endocrinopathies can lead to significant neurological consequences.