Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients. Issue 2 (12th January 2022)

• Record Type: Journal Article
• Authors: Sagandira, Cloudius R.; Nqeketo, Sinazo; Mhlana, Kanyisile; Sonti, Thembela; Gaqa, Sibongiseni; Watts, Paul
• Is Part Of: Reaction chemistry & engineering. Volume 7:Issue 2(2022)
• Page Start: 214
• Page End: 244
• Publication Date: 2022-01-12
• Subjects: Reaction mechanisms (Chemistry) -- Periodicals; Chemical engineering -- Periodicals; Chemical engineering; Reaction mechanisms (Chemistry); Periodicals; 547.705
• DOI: 10.1039/d1re00483b
• Languages: English
• ISSNs: 2058-9883

Abstract

Abstract : The convergence of end-to-end continuous flow synthesis with downstream processing, process analytical technology (PAT), artificial intelligence (AI), machine learning and automation in ensuring improved accessibility of quality medicines on demand. Abstract : Continuous flow chemistry has opened a new paradigm in both the laboratory and pharmaceutical industry. This review details the recently reported literature on continuous multistep telescoped synthesis of active pharmaceutical ingredients (APIs), inline flow downstream processing, in-process monitoring by process analytical technology (PAT) in flow, flow automation and artificial intelligence (AI) and robotics. We envisage that the integration of all these techniques can ensure an 'ideal' smart and efficient 21st century API chemical process that dramatically improves efficiency, agility, quality and flexibility in the manufacturing of pharmaceuticals.