Enzymatic Synthesis of Alkyl Glucosides by β‐Glucosidases in a 2‐in‐1 Deep Eutectic Solvent System. Issue 3 (19th November 2021)

• Record Type: Journal Article
• Authors: Delavault, André; Grüninger, Jens; Kapp, Daniel; Hollenbach, Rebecca; Rudat, Jens; Ochsenreither, Katrin; Syldatk, Christoph
• Is Part Of: Chemie Ingenieur Technik. Volume 94:Issue 3(2022)
• Page Start: 417
• Page End: 426
• Publication Date: 2021-11-19
• Subjects: Deep eutectic solvents -- β‐Glucosidase -- Glycolipid -- Renewables -- Tailor‐made biosurfactants; Chemical engineering -- Patents -- Periodicals; Chemical engineering -- Periodicals; Chemical industry -- Periodicals; Chemistry, Technical -- Periodicals; 660.05
• DOI: 10.1002/cite.202100150
• Languages: English
• ISSNs: 0009-286X

Abstract

Abstract: Alkyl glycosides are biodegradable surfactants with excellent physico‐chemical properties. Although their wide‐range application is considered ecofriendly, their synthesis is not due to the need for toxic organic solvents and corrosive acids as catalysts. Moreover, chemical synthesis results in complex mixtures rather than defined compounds. To overcome both disadvantages as well as the limited solubility of sugars in organic solvents, a highly selective enzymatic synthesis was set up with a β ‐glucosidase condensing D‐glucose and different fatty alcohols in a deep eutectic solvent. Abstract : The study achieved a highly selective synthesis of alkyl glycosides using a β ‐glucosidase that allowed condensation between D‐glucose and different fatty alcohols in a deep eutectic solvent (DES). Thereby, the reaction system overcomes limitations of low sugar solubility in organic solvents and need for complex protection/deprotection strategies.