Copper-catalyzed regio- and stereoselective fluorocarboalkynylation of alkynes. Issue 24 (12th October 2021)

• Record Type: Journal Article
• Authors: Zhao, Binlin; Zheng, Yukun; Zhu, Tianxiang; Wang, Mengning; Wang, Minyan; Ma, Mengtao
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 24(2021)
• Page Start: 6857
• Page End: 6862
• Publication Date: 2021-10-12
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo01201k
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : It is attractive to establish an efficient and practical platform affording functional compounds using readily available feedstocks as starting materials under mild conditions. Abstract : It is attractive to establish an efficient and practical platform affording functional compounds using readily available feedstocks as starting materials under mild conditions. We describe a direct copper-catalyzed fluorocarboalkynylation of the readily available alkynes with excellent regio- and stereoselectivity. A wide range of conjugated trifluoromethyl 1, 3-enynes were obtained in good yields by this operationally simple strategy. The mechanistic experiments and DFT calculation revealed that a radical-mediated process was involved in the catalytic cycle.