Access to azonanes via Pd-catalyzed decarboxylative [5 + 4] cycloaddition with exclusive regioselectivity. Issue 24 (11th November 2021)

• Record Type: Journal Article
• Authors: Liu, Yin; He, Yicheng; Liu, Yang; Wei, Kun; Guo, Wusheng
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 24(2021)
• Page Start: 7004
• Page End: 7008
• Publication Date: 2021-11-11
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo01405f
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An efficient approach for the synthesis of azonanes via Pd-catalyzed decarboxylative [5 + 4] cycloaddition has been developed. The reactions feature wide functional group tolerance with exclusive regioselectivity. Abstract : A highly efficient approach for the synthesis of azonanes via Pd-catalyzed decarboxylative [5 + 4] cycloaddition has been developed. This procedure utilizes methylene cyclic carbonates as a C5-dipole and 1-azadiene as a C4-synthon. The reactions could be performed at room temperature. The protocol features wide functional group tolerance with exclusive regioselectivity and generates CO2 as the only byproduct.