State-Of-Play for Cellular Therapies in Cardiac Repair and Regeneration. (27th August 2021)

• Record Type: Journal Article
• Authors: Vaka, Ramana; Davis, Darryl R.
• Is Part Of: Stem cells. Volume 39:Number 12(2021)
• Page Start: 1579
• Page End: 1588
• Publication Date: 2021-08-27
• Subjects: cardiac -- cellular therapy -- mesenchymal stem cells -- pluripotent stem cells -- stem cells; Cloning -- Periodicals; Clone cells -- Periodicals; Stem cells -- Periodicals; Cell Differentiation -- Periodicals; Cell Division -- Periodicals; Clone Cells -- Periodicals; Hematopoietic Stem Cells -- Periodicals; Stem Cells -- Periodicals; 571.84
• DOI: 10.1002/stem.3446
• Languages: English
• ISSNs: 1066-5099

Abstract

Abstract: Cardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease. In this article, we report on the "state-of-play" of cellular therapies for cardiac repair and regeneration. We outline the progression of new ideas from the preclinical literature to ongoing clinical trials. Recent data supporting the mechanics and mechanisms of myogenic and paracrine therapies are evaluated in the context of long-term cardiac engraftment. This discussion informs on promising new approaches to indicate future avenues for the field. : Cardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease. In this article, we report on the "state-of-play" of cellular therapies for cardiac repair and regeneration.