Application of Tonsil-Derived Mesenchymal Stem Cells in Tissue Regeneration: Concise Review. (25th July 2019)

• Record Type: Journal Article
• Authors: Oh, Se-Young; Choi, Young Min; Kim, Ha Yeong; Park, Yoon Shin; Jung, Sung-Chul; Park, Joo-Won; Woo, So-Youn; Ryu, Kyung-Ha; Kim, Han Su; Jo, Inho
• Is Part Of: Stem cells. Volume 37:Number 10(2019)
• Page Start: 1252
• Page End: 1260
• Publication Date: 2019-07-25
• Subjects: Mesenchymal stem cells -- Differentiation -- Tissue engineering -- Regenerative medicine -- Immunomodulation; Cloning -- Periodicals; Clone cells -- Periodicals; Stem cells -- Periodicals; Cell Differentiation -- Periodicals; Cell Division -- Periodicals; Clone Cells -- Periodicals; Hematopoietic Stem Cells -- Periodicals; Stem Cells -- Periodicals; 571.84
• DOI: 10.1002/stem.3058
• Languages: English
• ISSNs: 1066-5099

Abstract

Abstract : Since the discovery of stem cells and multipotency characteristics of mesenchymal stem cells (MSCs), there has been tremendous development in regenerative medicine. MSCs derived from bone marrow have been widely used in various research applications, yet there are limitations such as invasiveness of obtaining samples, low yield and proliferation rate, and questions regarding their practicality in clinical applications. Some have suggested that MSCs from other sources, specifically those derived from palatine tonsil tissues, that is, tonsil-derived MSCs (TMSCs), could be considered as a new potential therapeutic tool in regenerative medicine due to their superior proliferation rate and differentiation capabilities with low immunogenicity and ease of obtaining. Several studies have determined that TMSCs have differentiation potential not only into the mesodermal lineage but also into the endodermal as well as ectodermal lineages, expanding their potential usage and placing them as an appealing option to consider for future studies in regenerative medicine. In this review, the differentiation capacities of TMSCs and their therapeutic competencies from past studies are addressed. Stem Cells 2019;37:1252–1260 : Abstract : Schematic illustration of lineage differentiation of tonsil-derived mesenchymal stem cells.