MR1, an immunological periscope of cellular metabolism. (27th October 2021)

• Record Type: Journal Article
• Authors: Chancellor, Andrew; Vacchini, Alessandro; De Libero, Gennaro
• Is Part Of: International immunology. Volume 34:Number 3(2022)
• Page Start: 141
• Page End: 147
• Publication Date: 2021-10-27
• Subjects: antigen presentation -- MAIT -- metabolite antigens -- MR1T cells -- tumour metabolites; Immunology -- Periodicals; 616.079
• DOI: 10.1093/intimm/dxab101
• Languages: English
• ISSNs: 0953-8178

Abstract

Abstract: The discovery that major histocompatibility complex (MHC) class I-related molecule 1 (MR1) presents microbial antigens to mucosal-associated invariant T (MAIT) cells was a significant scientific milestone in the last decade. Surveillance for foreign metabolically derived antigens added a new class of target structures for immune recognition. The recent identification of a second family of MR1-restricted T cells, called MR1T cells, which show self-reactivity suggests the microbial antigens characterized so far may only represent a handful of the potential structures presented by MR1. Furthermore, the reactivity of MR1T cells towards tumours and not healthy cells indicates tight regulation in the generation of self-antigens and in MR1 expression and antigen loading. These novel and exciting observations invite consideration of new perspectives of MR1-restricted antigen presentation and its wider role within immunity and disease. Abstract : MR1-retricted T cells in health and disease Graphical Abstract: