Silver-catalyzed decarboxylative radical relay difluoroalkylation–carbocyclization: convenient access to CF2-containing quinolinones. Issue 24 (1st November 2021)

• Record Type: Journal Article
• Authors: Zhao, Feng; Guo, Sa; Zhang, Yan; Sun, Ting; Yang, Bing; Ye, Yong; Sun, Kai
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 24(2021)
• Page Start: 6895
• Page End: 6900
• Publication Date: 2021-11-01
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo01425k
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A practical Ag-catalyzed formal decarboxylation and radical difluoroalkylation–carbocyclization–hydrolysis route is established to construct a series of structurally diverse CF2 -containing N-heterocycles. Abstract : We report a practical Ag-catalyzed decarboxylative difluoroalkylation–carbocyclization reaction. Various structurally diverse gem -fluorinated quinolinones were obtained in moderate to good yields. Mechanistic studies suggested that the catalytic system involved a formal decarboxylation and subsequent radical difluoroalkylation–carbocyclization pathway.