Engineered stem cells targeting multiple cell surface receptors in tumors. (21st August 2019)

• Record Type: Journal Article
• Authors: Kavari, Sanam L.; Shah, Khalid
• Is Part Of: Stem cells. Volume 38:Number 1(2020)
• Page Start: 34
• Page End: 44
• Publication Date: 2019-08-21
• Subjects: adult stem cells -- cancer -- cell death -- cell surface receptors -- signal transduction; Cloning -- Periodicals; Clone cells -- Periodicals; Stem cells -- Periodicals; Cell Differentiation -- Periodicals; Cell Division -- Periodicals; Clone Cells -- Periodicals; Hematopoietic Stem Cells -- Periodicals; Stem Cells -- Periodicals; 571.84
• DOI: 10.1002/stem.3069
• Languages: English
• ISSNs: 1066-5099

Abstract

Abstract: Multiple stem cell types exhibit inherent tropism for cancer, and engineered stem cells have been used as therapeutic agents to specifically target cancer cells. Recently, stem cells have been engineered to target multiple surface receptors on tumor cells, as well as endothelial and immune cells in the tumor microenvironment. In this review, we discuss the rationales and strategies for developing multiple receptor-targeted stem cells, their mechanisms of action, and the promises and challenges they hold as cancer therapeutics. :