Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients. (20th May 2021)

• Record Type: Journal Article
• Authors: Ogata, Alana F; Cheng, Chi-An; Desjardins, Michaël; Senussi, Yasmeen; Sherman, Amy C; Powell, Megan; Novack, Lewis; Von, Salena; Li, Xiaofang; Baden, Lindsey R; Walt, David R
• Is Part Of: Clinical infectious diseases. Volume 74:Number 4(2022)
• Page Start: 715
• Page End: 718
• Publication Date: 2021-05-20
• Subjects: COVID-19 -- mRNA vaccine -- SARS-CoV-2 antigens -- immune responses -- spike; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab465
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. Eleven of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day 1 after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of immunoglobulin G (IgG) and immunoglobulin A (IgA).