Diabetic hypertriglyceridaemia and Alzheimer's disease: causal or not?. Issue 2 (29th April 2022)

• Record Type: Journal Article
• Authors: Takechi, Ryusuke; Lam, Virginie; Mamo, John C.L.
• Is Part Of: Current opinion in endocrinology, diabetes and obesity. Volume 29:Issue 2(2022)
• Page Start: 101
• Page End: 105
• Publication Date: 2022-04-29
• Subjects: Alzheimer's disease -- amyloid -- blood−brain barrier -- brain capillaries -- cardiometabolic -- dementia -- lipids -- lipoproteins -- type 2 diabetes mellitus; Endocrinology -- Periodicals; Diabetes -- Periodicals; Obesity -- Periodicals; Diabetes Mellitus -- Periodicals; Endocrine System Diseases -- Periodicals; Endocrine Glands -- Periodicals; Obesity -- Periodicals; Endocrinologie -- Périodiques; Diabète -- Périodiques; Obésité -- Périodiques; Diabetes; Endocrinology; Obesity; Periodicals; 616.4
• DOI: 10.1097/MED.0000000000000696
• Languages: English
• ISSNs: 1752-296X

Abstract

Abstract : Purpose of review: To summarize recent findings considering type II diabetes, or metabolic syndrome dyslipidaemia with risk for Alzheimer's disease. Recent findings: Population, genetic, clinical and preclinical studies support the hypothesis of increased risk for Alzheimer's disease in type 2 diabetes mellitus. The mechanisms are unclear. However, recent studies suggest that aberrations in the peripheral metabolism of triglyceride-rich-lipoproteins compromise the brain microvasculature. Summary: We review the literature of prediabetic metabolic syndrome and type 2 diabetes mellitus as a risk factor for Alzheimer's disease. We focus on a potential association with aberrations in the systemic metabolism of triglyceride-rich-lipoproteins reported over 18 months.