A Zr‐Based MOF with N‐heterocycle and its pH‐controlled drug release behavior. Issue 1 (12th November 2021)

• Record Type: Journal Article
• Authors: He, Qing; Shen, Jie; Guan, Xinghua; Han, Yuanbo; Jiang, Xiaoying; Shen, Xiaoan; Huang, Xiajuan; Chen, Yufeng; Lei, Chen; Xiao, Xiaoyan; Lin, Wenxin
• Is Part Of: Zeitschrift für anorganische und allgemeine Chemie. Volume 648:Issue 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-12
• Subjects: Metal-organic framework -- Biocompatibility -- Oral drug carrier -- pH-responsive; Chemistry, Inorganic -- Periodicals; Chemistry -- Periodicals; 540
• DOI: 10.1002/zaac.202100248
• Languages: English
• ISSNs: 0044-2313

Abstract

Abstract: A Zr‐based metal‐organic framework was synthesized by solvothermal method. It was designated as UiO‐67(bpy) since its structure matched well with UiO‐67 according to the X‐ray diffraction results. The cytotoxicity assay of UiO‐67(bpy) was measured and it revealed that UiO‐67(bpy) had excellent biocompatibility. UiO‐67(bpy) was used to load anti‐inflammatory drugs, and the loading capacity of diclofenac sodium (DS) of UiO‐67(bpy) reached 30.08 wt %. Furthermore, the DS@UiO‐67(bpy) exhibited a pH‐controlled drug deliver behavior. The DS released in simulated intestinal environment (pH 7.4) was about 20 times of that in simulated gastric environment (pH 2.0) after 12 h. UiO‐67(bpy) showed potential application prospects as an oral drug carrier. Abstract :