Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade. (13th July 2016)

• Record Type: Journal Article
• Authors: Lee, Valerie; Murphy, Adrian; Le, Dung T.; Diaz, Luis A.
• Is Part Of: Oncologist. Volume 21:Number 10(2016)
• Page Start: 1200
• Page End: 1211
• Publication Date: 2016-07-13
• Subjects: Microsatellite instability -- DNA mismatch repair -- Immunotherapy -- Colonic neoplasms -- Colorectal neoplasms -- Hereditary nonpolyposis; Oncology -- Periodicals; Tumors -- Periodicals; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Oncology; Tumors; Neoplasms; Electronic journals; Periodicals; Periodicals; 616.994
• DOI: 10.1634/theoncologist.2016-0046
• Languages: English
• ISSNs: 1083-7159

Abstract

Abstract : More than 1.6 million new cases of cancer will be diagnosed in the U.S. in 2016, resulting in more than 500, 000 deaths. Although chemotherapy has been the mainstay of treatment in advanced cancers, immunotherapy development, particularly with PD-1 inhibitors, has changed the face of treatment for a number of tumor types. One example is the subset of tumors characterized by mismatch repair deficiency and microsatellite instability that are highly sensitive to PD-1 blockade. Hereditary forms of cancer have been noted for more than a century, but the molecular changes underlying mismatch repair-deficient tumors and subsequent microsatellite unstable tumors was not known until the early 1990s. In this review article, we discuss the history and pathophysiology of mismatch repair, the process of testing for mismatch repair deficiency and microsatellite instability, and the role of immunotherapy in this subset of cancers. Abstract : In this review article, the history and pathophysiology of mismatch repair, the process of testing for mismatch repair deficiency and microsatellite instability, and the role of immunotherapy in a number of tumor types, including those that are highly sensitive to PD-1 blockade, are discussed.