Genetic Polymorphism of Matrix Metalloproteinase-9 and Susceptibility to Myocardial Infarction: A Meta-Analysis. (15th January 2022)

• Record Type: Journal Article
• Authors: Feng, Beili; Li, Hengdong
• Other Names: Pichini Simona Academic Editor.
• Is Part Of: Disease markers. Volume 2022(2022)
• Publication Date: 2022-01-15
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2022/5507153
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Objective . Current findings on the association between MMP-9 rs3918242 and susceptibility to myocardial infarction (MI) are inconsistent, and their definite relationship is discussed in this meta-analysis. Methods . Eligible literatures reporting MMP-9 rs3918242 and susceptibility to MI were searched in PubMed, Cochrane Library, CNRI, and VIP using keywords such as "MMP-9", "matrix metallopeptidase-9" and "myocardial infarction", "acute myocardial infarction", "AMI", and "polymorphism". Data from eligible literatures were extracted for calculating OR and corresponding 95% CI using RevMan 5.3 and STATA12.0. Results . Ten independent literatures reporting MMP-9 rs3918242 and susceptibility to MI were enrolled. Compared with subjects carrying CT&TT genotype of MMP-9 rs3918242, susceptibility to MI was lower in those carrying CC genotype (OR = 1.49, 95 % CI = 1.19 – 1.86, P = 0.0004 ). Such a significance was observed in the overdominant (OR = 1.27, 95 % CI = 1.14 – 1.41, P < 0.0001 ) and allele genetic models (OR = 1.43, 95 % CI = 1.17 – 1.74, P = 0.0005 ) as well. This finding was also valid in the Asian population. Conclusions . Mutation on MMP-9 rs3918242 has a potential relevance with susceptibility to MI.