Immunoglobulin G immune response to SARS-CoV-2 vaccination in people living with multiple sclerosis within Multiple Sclerosis Partners Advancing Technology and Health Solutions. (June 2022)

• Record Type: Journal Article
• Authors: Cohen, Jeffrey A; Bermel, Robert A; Grossman, Cynthia I; Hersh, Carrie M; Hyland, Megan; Mowry, Ellen M; Naismith, Robert; Naylor, Maria L; Nicholas, Jacqueline; Rajbhandar, Rajani; Singh, Carol M; Tintorè, Mar; Zabalza, Ana; Ziemssen, Tjalf; Williams, James R; Montalban, Xavier
• Is Part Of: Multiple sclerosis. Volume 28:Number 7(2022)
• Page Start: 1131
• Page End: 1137
• Publication Date: 2022-06
• Subjects: Multiple sclerosis -- disease-modifying therapy -- SARS-COV-2 vaccination -- humoral immune response -- MS PATHS -- optimal management; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/13524585211061343
• Languages: English
• ISSNs: 1352-4585

Abstract

Background: The impact of multiple sclerosis (MS) disease-modifying therapies (DMTs) on SARS-CoV-2 vaccination response is uncertain. Methods: Post-SARS-CoV-2 vaccination blood samples across multiple DMTs were tested for SARS-CoV-2 immunoglobulin G (IgG) response. Results: Three hundred twenty-two people with MS were included; 91.9% received an mRNA vaccine. Post-vaccination reactive IgG rates (IgG index > 1) were 40% for anti-CD20 (32/80 patients); 41% for sphingosine 1-phosphate receptor modulators (S1PRM, 16/39); and 100% for all other classes, including the no DMT group. Conclusion: Anti-CD20 therapies and S1PRMs reduce IgG response to SARS-CoV-2 vaccination; IgG response is preserved with other DMTs.