SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study. (June 2022)

• Record Type: Journal Article
• Authors: Sormani, Maria Pia; Schiavetti, Irene; Landi, Doriana; Carmisciano, Luca; De Rossi, Nicola; Cordioli, Cinzia; Moiola, Lucia; Radaelli, Marta; Immovilli, Paolo; Capobianco, Marco; Brescia Morra, Vincenzo; Trojano, Maria; Tedeschi, Gioacchino; Comi, Giancarlo; Battaglia, Mario Alberto; Patti, Francesco; Fragoso, Yara Dadalti; Sen, Sedat; Siva, Aksel; Furlan, Roberto; Salvetti, Marco
• Other Names: Abbadessa Gianmarco non-byline-author.; Aguglia Umberto non-byline-author.; Allegorico Lia non-byline-author.; Allegri Rossi Beatrice Maria non-byline-author.; Amato Maria Pia non-byline-author.; Annovazzi Pietro non-byline-author.; Antozzi Carlo non-byline-author.; Appendino Lucia non-byline-author.; Arena Sebastiano non-byline-author.; Baione Viola non-byline-author.; Balgera Roberto non-byline-author.; Barcella Valeria non-byline-author.; Baroncini Damiano non-byline-author.; Barrilà Caterina non-byline-author.; Battaglia Mario A. non-byline-author.; Bellacosa Alessandra non-byline-author.; Bellucci Gianmarco non-byline-author.; Bergamaschi Roberto non-byline-author.; Bergamaschi Valeria non-byline-author.; Bezzini Daiana non-byline-author.; Biolzi Beatrice non-byline-author.; Bisecco Alvino non-byline-author.; Bonavita Simona non-byline-author.; Borriello Giovanna non-byline-author.; Bosa Chiara non-byline-author.; Bosco Antonio non-byline-author.; Bovis Francesca non-byline-author.; Bozzali Marco non-byline-author.; Brambilla Laura non-byline-author.; Brescia Morra Vincenzo non-byline-author.; Brichetto Giampaolo non-byline-author.; Buccafusca Maria non-byline-author.; Bucciantini Elisabetta non-byline-author.; Bucello Sebastiano non-byline-author.; Buscarinu Maria Chiara non-byline-author.; Cabboi Maria Paola non-byline-author.; Calabrese Massimiliano non-byline-author.; Calabria Francesca non-byline-author.; Caleri Francesca non-byline-author.; Camilli Federico non-byline-author.; Caniatti Luisa Maria non-byline-author.; Cantello Roberto non-byline-author.; Capobianco Marco non-byline-author.; Capra Ruggero non-byline-author.; Capuano Rocco non-byline-author.; Carmisciano Luca non-byline-author.; Carta Patrizia non-byline-author.; Cavalla Paola non-byline-author.; Celani Maria Grazia non-byline-author.; Cellerino Maria non-byline-author.; Cerqua Raffaella non-byline-author.; Chisari Clara non-byline-author.; Clerici Raffaella non-byline-author.; Clerico Marinella non-byline-author.; Cocco Eleonora non-byline-author.; Cola Gaia non-byline-author.; Comi Giancarlo non-byline-author.; Confalonieri Paolo non-byline-author.; Conte Antonella non-byline-author.; Conti Marta Zaffira non-byline-author.; Cordano Christian non-byline-author.; Cordera Susanna non-byline-author.; Cordioli Cinzia non-byline-author.; Corea Francesco non-byline-author.; Correale Claudio non-byline-author.; Cottone Salvatore non-byline-author.; Crescenzo Francesco non-byline-author.; Curti Erica non-byline-author.; d'Ambrosio Alessandro non-byline-author.; D'Amico Emanuele non-byline-author.; Danni Maura Chiara non-byline-author.; d'Arma Alessia non-byline-author.; Dattola Vincenzo non-byline-author.; de Biase Stefano non-byline-author.; De Luca Giovanna non-byline-author.; De Mercanti Stefania Federica non-byline-author.; De Mitri Paolo non-byline-author.; De Rossi Nicola non-byline-author.; De Stefano Nicola non-byline-author.; Della Cava Marco non-byline-author.; di Napoli Mario non-byline-author.; Di Sapio Alessia non-byline-author.; Docimo Renato non-byline-author.; Dutto Anna non-byline-author.; Evangelista Luana non-byline-author.; Fanara Salvatore non-byline-author.; Ferraro Diana non-byline-author.; Ferrò Maria Teresa non-byline-author.; Filippi Massimo non-byline-author.; Fioretti Cristina non-byline-author.; Fratta Mario non-byline-author.; Frau Jessica non-byline-author.; Fronza Marzia non-byline-author.; Furlan Roberto non-byline-author.; Gajofatto Alberto non-byline-author.; Gallo Antonio non-byline-author.; Gallo Paolo non-byline-author.; Gasperini Claudio non-byline-author.; Ghazaryan Anna non-byline-author.; Giometto Bruno non-byline-author.; Gobbin Francesca non-byline-author.; Govone Flora non-byline-author.; Granella Franco non-byline-author.; Grange Erica non-byline-author.; Grasso Maria Grazia non-byline-author.; Guareschi Angelica non-byline-author.; Guaschino Clara non-byline-author.; Guerrieri Simone non-byline-author.; Guidetti Donata non-byline-author.; Iaffaldano Pietro non-byline-author.; Ianniello Antonio non-byline-author.; Iasevoli Luigi non-byline-author.; Immovilli Paolo non-byline-author.; Imperiale Daniele non-byline-author.; Infante Maria Teresa non-byline-author.; Inglese Matilde non-byline-author.; Iodice Rosa non-byline-author.; Iovino Aniello non-byline-author.; Konrad Giovanna non-byline-author.; Landi Doriana non-byline-author.; Lanzillo Roberta non-byline-author.; Lapucci Caterina non-byline-author.; Lavorgna Luigi non-byline-author.; L'Episcopo Maria Rita non-byline-author.; Leva Serena non-byline-author.; Liberatore Giuseppe non-byline-author.; Lo Re Marianna non-byline-author.; Longoni Marco non-byline-author.; Lopiano Leonardo non-byline-author.; Lorefice Lorena non-byline-author.; Lucchini Matteo non-byline-author.; Lus Giacomo non-byline-author.; Maimone Davide non-byline-author.; Malentacchi Maria non-byline-author.; Mallucci Giulia non-byline-author.; Malucchi Simona non-byline-author.; Mancinelli Chiara Rosa non-byline-author.; Mancinelli Luca non-byline-author.; Manganotti Paolo non-byline-author.; Maniscalco Teresa Giorgia non-byline-author.; Mantero Vittorio non-byline-author.; Marangoni Sabrina non-byline-author.; Marastoni Damiano non-byline-author.; Marfia Alessandra Girolama non-byline-author.; Marinelli Fabiana non-byline-author.; Marti Alessandro non-byline-author.; Martinelli Boneschi Filippo non-byline-author.; Masserano Zoli Federco non-byline-author.; Matta Francesca non-byline-author.; Mendozzi Laura non-byline-author.; Meucci Giuseppe non-byline-author.; Miante Silvia non-byline-author.; Miele Giuseppina non-byline-author.; Milano Eva non-byline-author.; Mirabella Massimiliano non-byline-author.; Missione Rosanna non-byline-author.; Moccia Marcello non-byline-author.; Moiola Lucia non-byline-author.; Montepietra Sara non-byline-author.; Monti Bragadin Margherita non-byline-author.; Montini Federico non-byline-author.; Motta Roberta non-byline-author.; Nardone Raffaele non-byline-author.; Nicoletti Carolina Gabri non-byline-author.; Nobile-Orazio Eduardo non-byline-author.; Nozzolillo Agostino non-byline-author.; Onofrj Marco non-byline-author.; Orlandi Riccardo non-byline-author.; Palmieri Anna non-byline-author.; Paolicelli Damiano non-byline-author.; Pasquali Livia non-byline-author.; Pastò Luisa non-byline-author.; Patti Francesco non-byline-author.; Pedrazzoli Elisabetta non-byline-author.; Perini Paola non-byline-author.; Pesci Ilaria non-byline-author.; Petracca Maria non-byline-author.; Petrone Alfredo non-byline-author.; Piantadosi Carlo non-byline-author.; Pietroboni Anna M. non-byline-author.; Pinardi Federica non-byline-author.; Ponzano Marta non-byline-author.; Portaccio Emilio non-byline-author.; Pozzato Mattia non-byline-author.; Pozzilli Carlo non-byline-author.; Prosperini Luca non-byline-author.; Protti Alessandra non-byline-author.; Radaelli Marta non-byline-author.; Ragonese Paolo non-byline-author.; Rasia Sarah non-byline-author.; Realmuto Sabrina non-byline-author.; Repice Anna non-byline-author.; Rigoni Eleonora non-byline-author.; Rilla Maria Teresa non-byline-author.; Rinaldi Francesca non-byline-author.; Romano Calogero Marcello non-byline-author.; Ronzoni Marco non-byline-author.; Rovaris Marco non-byline-author.; Ruscica Francesca non-byline-author.; Sabattini Loredana non-byline-author.; Salemi Giuseppe non-byline-author.; Salvetti Marco non-byline-author.; Saraceno Lorenzo non-byline-author.; Sartori Alessia non-byline-author.; Sartori Arianna non-byline-author.; Sbragia Elvira non-byline-author.; Scandellari Cinzia non-byline-author.; Scarano Giuditta Ilaria non-byline-author.; Scarano Valentina non-byline-author.; Schiavetti Irene non-byline-author.; Schillaci Valentina non-byline-author.; Sessa Maria non-byline-author.; Sgarito Caterina non-byline-author.; Sibilia Grazia non-byline-author.; Siciliano Gabriele non-byline-author.; Signori Alessio non-byline-author.; Signoriello Elisabetta non-byline-author.; Sinisi Leonardo non-byline-author.; Sireci Francesca non-byline-author.; Sola Patrizia non-byline-author.; Solaro Claudio non-byline-author.; Sormani Maria Pia non-byline-author.; Sotgiu Stefano non-byline-author.; Sparaco Maddalena non-byline-author.; Stromillo Maria Laura non-byline-author.; Strumia Silvia non-byline-author.; Susani Laura Emanuela non-byline-author.; Tabiadon Giulietta non-byline-author.; Teatini Francesco non-byline-author.; Tedeschi Gioacchino non-byline-author.; Tomassini Valentina non-byline-author.; Tonietti Simone non-byline-author.; Torri Clerici Valentina non-byline-author.; Tortorella Carla non-byline-author.; Toscano Simona non-byline-author.; Totaro Rocco non-byline-author.; Trojano Maria non-byline-author.; Trotta Maria non-byline-author.; Turano Gabriella non-byline-author.; Ulivelli Monica non-byline-author.; Valentino Manzo non-byline-author.; Vaula Giovanna non-byline-author.; Vecchio Domizia non-byline-author.; Vercellino Marco non-byline-author.; Verrengia Elena Pinuccia non-byline-author.; Vianello Marika non-byline-author.; Virgilio Eleonora non-byline-author.; Vitetta Francesca non-byline-author.; Vollaro Stefano non-byline-author.; Zaffaroni Mauro non-byline-author.; Zampolini Mauro non-byline-author.; Zarbo Ignazio Roberto non-byline-author.; Zito Antonio non-byline-author.; Zuliani Luigi non-byline-author.;
• Is Part Of: Multiple sclerosis. Volume 28:Number 7(2022)
• Page Start: 1034
• Page End: 1040
• Publication Date: 2022-06
• Subjects: Multiple sclerosis -- coronavirus -- Sars-COV-2 -- immunomodulatory therapies -- immunosuppressive therapies; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/13524585211035318
• Languages: English
• ISSNs: 1352-4585

Abstract

Background: The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of the pandemic, serological tests became routinely available. Objective: To evaluate the seroprevalence of anti-SARS-CoV-2 antibodies according to the use of disease-modifying therapy (DMT) in a subset of patients included in the MuSC-19 data set who had undergone a serological test. Methods: We evaluated the association between positive serological test results and time elapsed since infection onset, age, sex, Expanded Disability Status Scale score, comorbidities and DMT exposure using a multivariable logistic model. Results: Data were collected from 423 patients (345 from Italy, 61 from Turkey and 17 from Brazil) with a serological test performed during follow-up. Overall, 325 out of 423 tested patients (76.8%) had a positive serological test. At multivariate analysis, therapy with anti-CD20 was significantly associated with a reduced probability of developing antibodies after COVID-19 (odds ratio (OR) = 0.20, p = 0.002). Conclusion: Patients with MS maintain the capacity to develop humoral immune response against SARS-COV-2, although to a lesser extent when treated with anti-CD20 drugs. Overall, our results are reassuring with respect to the possibility to achieve sufficient immunization with vaccination.