SXR rs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome. (July 2016)

• Record Type: Journal Article
• Authors: Turolo, Stefano; Edefonti, Alberto; Lepore, Marta; Ghio, Luciana; Cuzzoni, Eva; Decorti, Giuliana; Pasini, Andrea; Materassi, Marco; Malaventura, Cristina; Pugliese, Fabrizio; Montini, Giovanni
• Is Part Of: Pharmacogenomics. Volume 17:Number 11(2016)
• Page Start: 1227
• Page End: 1233
• Publication Date: 2016-07
• Subjects: idiopathic nephrotic syndrome -- steroids -- steroid-resistant -- SXR; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs-2016-0029
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: of the study was to analyse the impact of SXR rs3842689 polymorphism on the response to corticosteroids in pediatric idiopathic nephrotic syndrome.Patients & methods: 66 children (56 steroid-sensitive, ten steroid-resistant) were studied for SXR gene polymorphism distribution.Results: Steroid sensitive patients accounted for 96% of cases with In/In polymorphism, but only for 53% of cases with Del/Del polymorphism At odds ratio analysis, Del/Del represented a clear risk factor of steroid resistance (OR: 20.57; p = 0.009), while In/In was a favourable prognostic factor of steroid sensitivity.Conclusion: The analysis of SXR polymorphism is a promising tool to predict both the favourable response to corticosteroids and the risk of developing steroid resistance.