Association Between Soluble Notch Ligand Delta-like Ligand 1 and Bleeding Complications in Patients With Dengue Fever Infection. (10th August 2021)

• Record Type: Journal Article
• Authors: Hildebrand, Dagmar; Nurjadi, Dennis; Hoan, Nghiem Xuan; Linh, Mai Thanh Hai; Sang, Vu Viet; Bang, Mai Hong; Pallerla, Srinivas Reddy; Kremsner, Peter G; Heeg, Klaus; Song, Le Huu; Velavan, Thirumalaisamy P
• Is Part Of: Journal of infectious diseases. Volume 225:Number 3(2022)
• Page Start: 476
• Page End: 480
• Publication Date: 2021-08-10
• Subjects: DLL1 -- Notch -- Dengue virus -- dengue hemorrhagic fever (DHF) -- bleeding -- plasma leakage -- predictive marker; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab404
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Bleeding associated with endothelial damage is a key feature of severe dengue fever. In the current study, we investigated whether Notch ligands were associated with bleeding in 115 patients with confirmed dengue infection in Vietnam. Soluble Notch ligands were determined by means of enzyme-linked immunosorbent assay. Seventeen of 115 patients (14.8%) experienced bleeding manifestations. High soluble delta-like ligand 1 (sDLL1) plasma levels was associated with bleeding (median, 15 674 vs 7117 pg/mL; P < .001). Receiver operating characteristic (ROC) curve analysis demonstrated that sDLL1 had the best test performance (area under the ROC curve, 0.852), with 88% sensitivity and 84% specificity. The combination with alanine aminotransferase and aspartate aminotransferase slightly increased sDLL1 performance. sDLL1 may be useful to guide clinical management of patients with patients in endemic settings. Abstract : Bleeding associated with endothelial damage is a key feature of severe dengue fever. High plasma levels of soluble Notch delta-like ligand 1 (sDLL1) are associated with bleeding. sDLL1 may be useful to guide clinical management of dengue in endemic settings.