Liver-Unrelated Comorbid Conditions Do Not Affect Cognitive Performance or Hepatic Encephalopathy Progression in Cirrhosis. (18th December 2021)

• Record Type: Journal Article
• Authors: Acharya, Chathur; Nadhem, Omar; Shaw, Jawaid; Hassouneh, Ramzi; Fagan, Andrew; McGeorge, Sara; Sterling, Richard K.; Puri, Puneet; Fuchs, Michael; Luketic, Velimir; Sanyal, Arun J.; Wade, James B.; Gilles, HoChong S.; Heuman, Douglas M.; Tinsley, Felicia; Matherly, Scott; Lee, Hannah; Siddiqui, Mohammad S.; Thacker, Leroy R.; Bajaj, Jasmohan S.
• Is Part Of: American journal of gastroenterology. Volume 116:Number 12(2021)
• Page Start: 2385
• Page End: 2389
• Publication Date: 2021-12-18
• Subjects: Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Gastrointestinal Diseases -- Periodicals; Electronic journals; Periodicals; 616.33
• DOI: 10.14309/ajg.0000000000001346
• Languages: English
• ISSNs: 0002-9270

Abstract

Abstract : INTRODUCTION: We aimed to determine the effect of comorbidities on covert hepatic encephalopathy (CHE) diagnosis and overt hepatic encephalopathy (OHE) development. METHODS: Cirrhotic outpatients underwent CHE testing and 2-year follow-up. Cox regression was performed for time to OHE. In total, 700 patients (60 years, 84% men, model for end-stage liver disease 11) and 33% prior OHE underwent testing and follow-up. RESULTS: Major comorbidities were hypertension (54%), diabetes (35%), and depression (29%). Common medications were proton pump inhibitor (49%), beta-blockers (32%), and opioids (21%). Approximately 90 (40%) prior-OHE patients developed recurrence 93 (30, 206) days post-testing predicted only by liverrelated variables. DISCUSSION: Demographics, cirrhosis characteristics, and opioid use, but not other comorbid conditions, were associated with CHE diagnosis and OHE progression.