Performance of plasma calprotectin as a biomarker of early sepsis: a pilot study. (August 2016)

• Record Type: Journal Article
• Authors: Simm, Mikael; Söderberg, Ewa; Larsson, Anders; Castegren, Markus; Nilsen, Tom; Eriksson, Mats; Lipcsey, Miklos
• Is Part Of: Biomarkers in medicine. Volume 10:Number 8(2016)
• Page Start: 811
• Page End: 818
• Publication Date: 2016-08
• Subjects: calprotectin -- sepsis -- systemic inflammatory response syndrome; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm-2016-0032
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: To determine the performance of plasma calprotectin as a marker of sepsis on intensive care unit (ICU) admission and as a marker of mortality day 30 post-ICU admission.Materials & methods: Consecutive ICU patients were allocated to: sepsis (n = 15), postoperative inflammation (n = 23) and intoxication without inflammation (n = 7) groups.Results: Calprotectin was 4.3 (2.6–8.2; mg/l; median [interquartile range]) in the sepsis, 2.8 (1.6–4.4) in the postoperative and 0.7 (0.4–1.6) in the intoxication groups. Area under the receiver operating characteristic curve for sepsis versus intoxication group was: 0.95, for sepsis versus postoperative groups: 0.65 and for survivors versus nonsurvivors: 0.70.Conclusion: Calprotectin was a sensitive marker of systemic inflammation, is a potential sepsis marker and performed well as mortality predictor in this pilot study.