Cover Feature: Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity (ChemMedChem 3/2020). (5th February 2020)

• Record Type: Journal Article
• Authors: Fois, Benedetta; Skok, Žiga; Tomašič, Tihomir; Ilaš, Janez; Zidar, Nace; Zega, Anamarija; Peterlin Mašič, Lucija; Szili, Petra; Draskovits, Gábor; Nyerges, Ákos; Pál, Csaba; Kikelj, Danijel
• Is Part Of: ChemMedChem. Volume 15:Number 3(2020)
• Page Start: 264
• Page End: 264
• Publication Date: 2020-02-05
• Subjects: antibiotics -- ciprofloxacin -- drug discovery -- dual inhibitors -- gyrase A -- gyrase B -- hybrids; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.202000031
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract : The Cover Feature shows a representative DNA gyrase B (GyrB) inhibitor/ciprofloxacin hybrid that penetrates into Escherichia coli and displays antibacterial activity. The observed antibacterial activity of these hybrid molecules is mainly due to interaction with GyrA and/or ParC and not with the GyrB subunit, because inhibition of GyrB by the presented hybrids, although present, is not strong enough to provide a substantial contribution to the observed antibacterial activity. More information can be found in the Communication by Danijel Kikelj et al. on page 265 in Issue 3, 2020 (DOI: 10.1002/cmdc.201900607 ).