Looking for new anabolic treatment from rare diseases of bone formation. Issue 2 (February 2021)

• Record Type: Journal Article
• Authors: Rossi, Michela; Battafarano, Giulia; De Martino, Viviana; Scillitani, Alfredo; Minisola, Salvatore; Del Fattore, Andrea
• Is Part Of: Journal of endocrinology. Volume 248:Issue 2(2021)
• Page Start: R29
• Page End: R40
• Publication Date: 2021-02
• Subjects: bone diseases -- osteoblast -- bone formation; Endocrinology -- Periodicals; 616.4005
• DOI: 10.1530/JOE-20-0285
• Languages: English
• ISSNs: 0022-0795

Abstract

Abstract : Bone remodelling is a complex mechanism regulated by osteoclasts and osteoblasts and perturbation of this process leads to the onset of diseases, which may be characterised by altered bone erosion or formation. In this review, we will describe some bone formation-related disorders as sclerosteosis, van Buchem disease, hypophosphatasia and Camurati–Engelmann disease. In the past decades, the research focused on these rare disorders offered the opportunity to understand important pathways regulating bone formation. Thus, the identification of the molecular defects behind the etiopathology of these diseases will open the way for new therapeutic approaches applicable also to the management of more common bone diseases including osteoporosis.