Conductive biomaterials for cardiac repair: A review. (February 2022)

• Record Type: Journal Article
• Authors: Li, Yimeng; Wei, Leqian; Lan, Lizhen; Gao, Yaya; Zhang, Qian; Dawit, Hewan; Mao, Jifu; Guo, Lamei; Shen, Li; Wang, Lu
• Is Part Of: Acta biomaterialia. Volume 139(2022)
• Page Start: 157
• Page End: 178
• Publication Date: 2022-02
• Subjects: Conductive biomaterials -- Cardiac patch -- Cardiac repair -- Electrical stimulation -- Tissue engineering; MI Myocardial infarction -- CMs Cardiomyocytes -- CPs Conductive polymers -- PPy Polypyrrole -- PANi Polyaniline -- PTh Polythiophene -- PEDOT Poly (3, 4-ethylene dioxythiophene) -- PSS Poly (styrene sulfonate) -- CNTs Carbon nanotubes -- GO Graphene oxide -- rGO Reduced graphene oxide -- PEG Polyethylene glycol -- PLA Polylactic acid -- PLGA Poly(lactic-co-glycolic acid) -- PCL Polycaprolactone -- PU Polyurethane -- CS Chitosan -- ECM Extracellular matrix -- HPAE-Py Poly (amino ester)-pyrrole -- CS-AT Chitosan-graft-aniline tetramer -- PEG-DA Dibenzaldehyde-terminated poly(ethylene glycol) -- AuNPs Gold nanoparticles -- GelMA Gelatin methacrylate -- MeTro Methacryloyl-substituted tropoelastin -- HEMA Hydroxyethyl methacrylate -- NRCMs Neonatal rat primary cardiomyocytes -- Cx43 Connexin 43 -- hMSCs Human mesenchymal stem cells -- CNTf CNT fibers -- NFYs Nanofiber yarns -- PGS Poly(glycerol sebacate) -- GATA4 GATA Binding Protein 4 -- NKX2.5 NK2 Homeobox 5 -- P(Py-PyCOOH) Poly(pyrrole-co-(1-(2-carboxyethyl)pyrrole)) -- DOPA Dopamine -- PAMB Poly-3-amino-4-methoxybenzoic acid -- hiPSC-CMs Human induced pluripotent stem cell-derived cardiomyocytes -- NMCMs Neonatal mouse cardiomyocytes -- SC-CMs Stem cell-derived cardiomyocytes -- ROI Regions of interest -- hESC-CMs Human embryonic stem cells-derived cardiomyocytes -- BADSCs Brown adipose-derived stem cells -- cTnT Cardiac troponin T -- 5-aza 5-azacytidine -- NPPA Natriuretic Peptide A -- TNNT2 Troponin T2 -- TGFB1 Transforming Growth Factor Beta1 -- ISL1 ISL LIM Homeobox 1 -- ACTN2 Actinin Alpha 2 -- TNNI3 troponin I3 -- MYH6 Myosin Heavy Chain 6 -- MYH7 Myosin Heavy Chain 7 -- MYL7 Myosin Light Chain 7 -- MYBPC3 Myosin Binding Protein C3 -- GJA1 Gap Junction Protein Alpha 1 -- CDH2 Cadherin 2 -- TJP1 Tight Junction Protein 1 -- RYR2 Ryanodine Receptor 2 -- CACNA1C Calcium Voltage-Gated Channel Subunit Alpha1 C -- SLC8A1 Solute Carrier Family 8 Member A1 -- SCN5A Sodium Voltage-Gated Channel Alpha Subunit 5 -- KCNQ1 Potassium Voltage-Gated Channel Subfamily Q Member 1 -- KCNH2 Potassium Voltage-Gated Channel Subfamily H Member 2 -- KCND3 Potassium Voltage-Gated Channel Subfamily D Member 3 -- KCNJ12 Potassium Voltage-Gated Channel Subfamily J Member 12 -- FAK Focal adhesion kinase -- ERK Extracellular signal-regulated kinase -- YAP Yes-associated protein -- PKC Protein kinase C -- LV Left ventricular -- FS Fractional shortening; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1016/j.actbio.2021.04.018
• Languages: English
• ISSNs: 1742-7061

Abstract

Abstract: Myocardial infarction (MI) is one of the fatal diseases in humans. Its incidence is constantly increasing annually all over the world. The problem is accompanied by the limited regenerative capacity of cardiomyocytes, yielding fibrous scar tissue formation. The propagation of electrical impulses in such tissue is severely hampered, negatively influencing the normal heart pumping function. Thus, reconstruction of the internal cardiac electrical connection is currently a major concern of myocardial repair. Conductive biomaterials with or without cell loading were extensively investigated to address this problem. This article introduces a detailed overview of the recent progress in conductive biomaterials and fabrication methods of conductive scaffolds for cardiac repair. After that, the advances in myocardial tissue construction in vitro by the restoration of intercellular communication and simulation of the dynamic electrophysiological environment are systematically reviewed. Furthermore, the latest trend in the study of cardiac repair in vivo using various conductive patches is summarized. Finally, we discuss the achievements and shortcomings of the existing conductive biomaterials and the properties of an ideal conductive patch for myocardial repair. We hope this review will help readers understand the importance and usefulness of conductive biomaterials in cardiac repair and inspire researchers to design and develop new conductive patches to meet the clinical requirements. Statement of significance: After myocardial infarction, the infarcted myocardial area is gradually replaced by heterogeneous fibrous tissue with inferior conduction properties, resulting in arrhythmia and heart remodeling. Conductive biomaterials have been extensively adopted to solve the problem. Summarizing the relevant literature, this review presents an overview of the types and fabrication methods of conductive biomaterials, and focally discusses the recent advances in myocardial tissue construction in vitro and myocardial repair in vivo, which is rarely covered in previous reviews. As well, the deficiencies of the existing conductive patches and their construction strategies for myocardial repair are discussed as well as the improving directions. Confidently, the readers of this review would appreciate advantages and current limitations of conductive biomaterials/patches in cardiac repair. Graphical abstract: Image, graphical abstract